Eli Lilly
12 medicines explained
Verzenio (abemaciclib) is an oral CDK4/6 inhibitor from Eli Lilly. It blocks cyclin-dependent kinases 4 and 6, keeps the retinoblastoma (Rb) protein unphosphorylated, and arrests cancer cells in the G1 phase before they can replicate their DNA. It is used, mostly alongside endocrine therapy, in hormone receptor-positive, HER2-negative breast cancer.
Breast cancer cells grow because molecular "accelerators" called CDK4 and CDK6 keep telling them to divide. Abemaciclib is a kinase inhibitor that swi
Olumiant (baricitinib) is an oral Janus kinase inhibitor from Eli Lilly. By damping JAK-STAT signalling it reduces inflammatory cytokine activity, and is used in rheumatoid arthritis after TNF blockers, in hospitalized adults with severe COVID-19, and in severe alopecia areata.
Many inflammatory diseases are driven by cytokines, chemical messages that tell immune cells to stay active. Those messages are relayed inside cells b
Keflex (cephalexin) is a first-generation cephalosporin antibiotic that kills bacteria by dismantling their cell walls. It is used for susceptible infections of the respiratory tract, middle ear, skin, bones and urinary tract.
Bacteria need a strong outer wall to keep their shape and survive. Cephalexin belongs to the cephalosporin family of antibiotics and blocks the enzyme
Trulicity (dulaglutide) is a once-weekly GLP-1 receptor agonist from Eli Lilly for type 2 diabetes. It boosts insulin when glucose is high, calms glucagon and slows stomach emptying, improving blood sugar and reducing major cardiovascular events in at-risk adults.
Dulaglutide mimics a natural hormone, GLP-1, that helps coordinate the body's response to food. It stimulates insulin release when blood sugar rises,
Cymbalta (duloxetine) is a serotonin–norepinephrine reuptake inhibitor used for depression, generalized anxiety disorder, diabetic nerve pain, fibromyalgia, and chronic musculoskeletal pain. By boosting both serotonin and norepinephrine in the brain and spinal cord, it lifts mood and also turns down the volume on chronic pain signals.
Duloxetine belongs to a group of medicines called serotonin–norepinephrine reuptake inhibitors, or SNRIs. Nerve cells use two chemicals — serotonin an
Emgality (galcanezumab) is a monoclonal antibody from Eli Lilly that binds and neutralizes calcitonin gene-related peptide (CGRP), a key signaling molecule in migraine. Given once monthly by injection, it prevents migraine in adults and treats episodic cluster headache.
Galcanezumab is an antibody that targets calcitonin gene-related peptide (CGRP), a small protein released during migraine and cluster headache attacks
Humalog (insulin lispro) is a rapid-acting insulin from Eli Lilly. Two swapped amino acids make it absorb quickly after injection, so it covers the rise in blood sugar that follows a meal, and it is used in type 1 and type 2 diabetes.
Insulin is the hormone that lets cells absorb glucose from the blood. After a meal, blood sugar rises quickly, and the body needs a fast burst of insu
Taltz (ixekizumab) is an interleukin-17A inhibitor from Eli Lilly that neutralises a key cytokine driving inflammation in skin, joints, and spine. It treats moderate-to-severe plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis in adults.
Ixekizumab is an injection that blocks a protein called interleukin-17A (IL-17A). IL-17A is a messenger released by overactive immune cells that tells
Ebglyss (lebrikizumab) is a monoclonal antibody from Eli Lilly that selectively neutralises interleukin-13, a key driver of type 2 inflammation in atopic dermatitis. It is used in moderate-to-severe disease in adults and adolescents when topical treatment is not enough.
In atopic dermatitis the immune system overproduces inflammatory signals, and IL-13 is one of the most important. It promotes itching, weakens the ski
Cialis (tadalafil) is a PDE5 inhibitor from Eli Lilly. By blocking the enzyme that breaks down cGMP, it enhances blood flow to the penis during sexual stimulation for erectile dysfunction, and it also relaxes smooth muscle in the prostate and bladder to relieve symptoms of benign prostatic hyperplasia.
Tadalafil belongs to a class called PDE5 inhibitors. During sexual stimulation, the body releases chemicals that relax the smooth muscle in the penis
Forteo (teriparatide) is a parathyroid hormone analog from Eli Lilly. Given as a daily injection, it stimulates new bone formation and is used to treat osteoporosis in people at high risk of fracture, including postmenopausal women, men with primary osteoporosis, and patients on long-term glucocorticoids.
Teriparatide is a small piece of human parathyroid hormone, the body's own signal for bone remodeling. When given as a once-daily injection, it acts i
Mounjaro (tirzepatide) is an injectable dual GIP and GLP-1 receptor agonist from Eli Lilly. It improves blood sugar control in type 2 diabetes alongside diet and exercise, and in the European Union it is also approved for weight management in adults with obesity or overweight with a weight-related condition.
Tirzepatide is given by injection and activates the receptors for two natural gut hormones, GIP and GLP-1. Together these signals help the pancreas re