elexacaftor/tezacaftor/ivacaftorTrikafta
CFTR modulator combinationTrikafta (Kaftrio in Europe) combines elexacaftor, tezacaftor and ivacaftor from Vertex for cystic fibrosis. Two correctors help the defective CFTR channel reach the cell surface, and a potentiator opens it, restoring salt and water movement.
Cystic fibrosis is caused by mutations in the CFTR gene, which encodes a channel controlling salt and water movement on cell surfaces. When the channe
