Janssen

Abiraterone acetate (Zytiga) is an oral medicine that lowers the body's production of androgens by blocking an enzyme needed to make testosterone. It is used with prednisone to treat metastatic castration-resistant and castration-sensitive prostate cancer.

Abiraterone blocks an enzyme called CYP17A1 that the body uses to make testosterone and other androgens. Even when standard hormone therapy lowers tes

Erleada (apalutamide) is an oral androgen receptor inhibitor from Janssen for prostate cancer. It blocks the receptor that prostate tumour cells need to grow, and is used in non-metastatic castration-resistant disease and, with androgen deprivation therapy, in metastatic hormone-sensitive disease.

Prostate cancer cells usually need male hormones, called androgens, to grow. Treatments that lower androgen levels work for a while, but cancers can a

Invokana (canagliflozin) is an SGLT2 inhibitor from Janssen. It makes the kidneys excrete extra glucose, lowering blood sugar in type 2 diabetes, and it also reduces major cardiovascular events and diabetic kidney disease progression in at-risk adults.

The kidneys filter blood continuously and normally reclaim all the glucose so none is lost in urine. Canagliflozin blocks SGLT2, the transporter respo

Darzalex (daratumumab) is a monoclonal antibody from Janssen that targets CD38, a protein abundant on myeloma cells. It flags those cells for immune destruction and is used with standard combinations across multiple myeloma, from newly diagnosed to relapsed disease.

Multiple myeloma is a cancer of antibody-producing plasma cells, and these cells display large amounts of a surface protein called CD38. Daratumumab b

Tremfya (guselkumab) is a monoclonal antibody from Janssen that selectively blocks interleukin-23, a driver of psoriatic inflammation. It clears skin in plaque psoriasis and treats psoriatic arthritis, in adults and children from six years.

In psoriasis, the immune system mistakenly keeps skin cells inflamed and multiplying too fast. A signalling protein called IL-23 helps maintain that i

Remicade (infliximab) is a chimeric antibody that binds and neutralises TNF-alpha, one of the first biologics for inflammatory disease. Given by infusion, it is used in Crohn disease, ulcerative colitis, rheumatoid arthritis and other immune conditions.

In conditions such as Crohn disease and rheumatoid arthritis, the immune system produces too much TNF-alpha, a chemical that keeps inflammation active

Levofloxacin (Levaquin) is an oral and intravenous fluoroquinolone antibiotic used in adults for bacterial pneumonias, skin infections, urinary tract infections, chronic bacterial prostatitis, acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, and post-exposure inhalational anthrax and plague. It blocks bacterial enzymes needed to copy DNA, killing the bacteria. It should be reserved when alternative treatments are not suitable.

Levofloxacin is a fluoroquinolone antibiotic. It kills bacteria by blocking two enzymes that bacteria need to copy and repair their DNA: DNA gyrase an

Invega (paliperidone) is an atypical antipsychotic used for schizophrenia and schizoaffective disorder. It blocks dopamine D2 and serotonin 5-HT2A receptors, calming overactive signaling in thought and mood circuits. It is the major active metabolite of risperidone and is formulated as a once-daily extended-release tablet.

Paliperidone is an atypical antipsychotic that works mainly by blocking two types of receivers in the brain: dopamine D2 receptors and serotonin 5-HT2

Stelara (ustekinumab) is a monoclonal antibody from Janssen that blocks the p40 subunit shared by interleukin-12 and interleukin-23. It is used in plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis in adults, and in plaque psoriasis and psoriatic arthritis in children from 6 years of age.

Ustekinumab is given by injection and binds the p40 subunit shared by interleukin-12 (IL-12) and interleukin-23 (IL-23), two proteins that keep immune