GlaxoSmithKline
Source: https://www.gsk.com/
6 medicines explained
Amoxicillin is a broad-spectrum penicillin antibiotic that stops bacteria from building their cell walls. It is used for common bacterial infections such as pneumonia and skin, ear and urinary tract infections, and with other medicines to eliminate Helicobacter pylori in ulcer disease.
Bacteria need a strong outer wall to survive, and they build it with the help of enzymes called penicillin-binding proteins. Amoxicillin attaches to t
Jemperli (dostarlimab) is a PD-1 checkpoint inhibitor from GlaxoSmithKline. It reawakens T cells against mismatch repair-deficient cancers and is used in advanced endometrial cancer, alone or with chemotherapy, and in selected previously treated solid tumours.
T cells can destroy cancer, but many tumours switch them off through the PD-1 receptor. Dostarlimab is an antibody that blocks PD-1, preventing tumour
Nucala (mepolizumab) is a monoclonal antibody from GlaxoSmithKline that neutralises interleukin-5, the key survival signal for eosinophils. It prevents attacks in severe eosinophilic asthma and treats chronic rhinosinusitis with nasal polyps.
Some people with severe asthma have too many eosinophils, a type of immune cell, inflaming their airways. These cells depend on a signal called IL-5 t
Zejula (niraparib) is an oral PARP inhibitor from GlaxoSmithKline used as maintenance treatment for advanced ovarian, fallopian tube, or primary peritoneal cancer that has responded to platinum-based chemotherapy. It blocks DNA repair enzymes cancer cells depend on, so DNA damage accumulates and the cells die.
Niraparib blocks PARP-1 and PARP-2, the enzymes cells use to repair single-strand DNA breaks. When PARP is inhibited, unrepaired breaks accumulate. Ca
Ventolin (salbutamol, also known as albuterol) is a short-acting inhaled bronchodilator. It treats or prevents bronchospasm in people aged 4 years and older with reversible obstructive airway disease and prevents exercise-induced bronchospasm.
Salbutamol is a short-acting sympathomimetic drug breathed in through an inhaler. It stimulates beta2-adrenergic receptors in the lungs, which activat
Shingrix is GlaxoSmithKline's recombinant, adjuvanted herpes zoster vaccine. It contains varicella-zoster virus glycoprotein E and stimulates T-cell and antibody responses that prevent shingles and post-herpetic neuralgia in adults aged 50 and older and in adults aged 18 and older at increased risk.
Shingrix contains glycoprotein E, a single protein from the surface of the varicella-zoster virus, combined with an adjuvant. It is a recombinant subu